If you’ve just started your weight loss journey with the Wegovy injection, or you’re considering it, it’s natural to wonder what the first month will be like. At Vivo Pharmacy, we support patients throughout their treatment and understand that the early stages can bring a mix of excitement and uncertainty.

Wegovy (semaglutide) is a once-weekly injection that mimics a hormone in the body called GLP-1. This hormone helps regulate appetite and slows digestion, leading to reduced hunger and lower calorie intake. But how quickly will you notice changes, and what side effects should you expect?

Here’s a week-by-week breakdown of what typically happens during the first four weeks on the Wegovy injection—plus some helpful lifestyle tips to support your success.

Week 1: Starting Gently

In your first week, you’ll begin with the lowest dose (0.25mg) of the Wegovy injection. This is designed to allow your body to adjust gradually and minimise side effects.

Most people won’t notice a dramatic reduction in appetite just yet. However, some patients do report feeling slightly fuller after meals or being less interested in snacking. This is a good time to observe your eating patterns and start making conscious changes.

Common side effects this week may include:

• –> Mild nausea

• –> Bloating or wind

• –> A slight change in bowel habits

Lifestyle tips:

• –> Eat slowly and stop when you feel satisfied

• –> Choose smaller portions and avoid fatty or greasy foods

• –> Stay well hydrated—aim for 6–8 glasses of water daily

This first week is mostly about getting comfortable with the injection process and setting a healthy routine.

Week 2: Subtle Changes Begin

By the second week, some patients begin to feel a more noticeable decrease in appetite. You may find you’re:

• –> Less hungry between meals

• –> Eating smaller portions without trying

• –> Skipping snacks or craving lighter options

Side effects may still include nausea or a sense of fullness, but they often settle if you’ve kept meals light and avoided trigger foods.

Lifestyle tips:

• –> Plan meals ahead to avoid unhealthy choices

• –> Keep track of your water intake and try herbal teas if hydration is a struggle

• –> Consider starting light physical activity such as walking or gentle stretching

Your weight may begin to shift slightly, but don’t worry if you haven’t seen changes yet—it’s still early days.

Week 3: Appetite Regulation Strengthens

By week three, the Wegovy injection often begins to take a more noticeable effect on appetite control. Many patients tell us this is when they truly start feeling in control of their hunger.

You might:

• –> Feel fuller after just a few bites

• –> Have more stable energy throughout the day

• –> Naturally reduce portion sizes without feeling deprived

Side effects such as nausea and fatigue tend to lessen by this stage, especially if you’ve been mindful about what and how you eat.

Lifestyle tips:

• –> Focus on balanced meals with protein, fibre and healthy fats

• –> Keep a journal to track progress, mood and appetite changes

• –> Set a regular sleep schedule to support weight loss and wellbeing

At Vivo Pharmacy, we often check in with patients at this stage to offer encouragement and adjust plans if needed.

Week 4: Building New Habits

By the end of your first month, most patients are settling into their routine and beginning to see measurable results. While individual progress varies, it’s not uncommon to see a modest reduction in weight and waist circumference by now.

More importantly, you may feel:

• –> More in control around food

• –> Less emotionally attached to eating

• –> Motivated to continue with healthy habits

Your dose will soon increase to 0.5mg in the next stage, which can bring stronger appetite suppression—but also a brief return of mild side effects as your body adjusts.

Lifestyle tips:

• –> Reassess your goals and celebrate small wins

• –> Experiment with new, healthy recipes to keep meals interesting

• –> Speak with our team if you’re unsure about anything or need support

What Comes Next?

After your first month, you’ll move on to the next dose as directed by your pharmacist or prescriber. The gradual increase in dosage helps your body adapt while maximising results over time.

Remember, the Wegovy injection is not a magic solution—it works best when paired with long-term lifestyle changes, including improved diet, regular movement, and support from professionals.

We’re With You Every Step of the Way

At Vivo Pharmacy, we don’t just supply medication—we support you through your journey. If you have questions about the Wegovy injection, need advice on managing side effects, or want help with healthy eating habits, our expert team is here to guide you.

Contact us to book your consultation with Vivo Pharmacy today, and take your first step towards sustainable weight loss—with the confidence that comes from expert care and real results.

This blog was written on behalf of Vivo Pharmacy by Pharmacy Mentor.